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HIV Modes of
Transmission,
Clinical Manifestations,
and Cases in the Public
HIV: Modes of Transmission
HIV can be transmitted from person to person through infected blood, semen or vaginal
secretions, which have the highest concentrations of the virus and perinatally from mother
to child. Breast milk has also been identified as a possible source of infection.
Although they may contain minute quantities of viral material, urine, tears, saliva and
perspiration have never been implicated in the spread of HIV. To date the CDC has only
investigated one case of HIV infection where transmission is believed to have
occurred during kissing. However, the transmission was attributed to contact with blood,
rather than saliva.a
Clinical Manifestations of HIV Infection
The course of HIV infection can vary considerably among individuals. The mean
interval from infection to the development of AIDS is 10-11 years.b
The spectrum of HIV infection ranges from an asymptomatic state to severe
immunodeficiency with associated opportunistic infections, neoplasms, and other
conditions. Initial infection can be followed by an acute flu-like illness with fever,
lymphadenopathy, sweats, myalgia, arthralgia, rash, malaise, sore throat, and headache.
The risk of disease progression increases with the duration of infection. Less than 5%
of HIV-infected adults develop AIDS within 2 years of infection; without therapy,
approximately 20-25% develop AIDS within 6 years after infection, and 50% within 10 years.
Although over 23 diseases/conditions have been identified as AIDS indicators, P. carinii
pneumonia, HIV wasting syndrome, and candidiasis of the esophagus are the most common.
HIV Infectionc
Through June 30, 1997, a cumulative total of 612,078 persons with AIDS were reported to
CDC by state and territorial health departments (table 1). Of these, 84 percent were
adult/adolescent men, 15 percent were adult/adolescent women, and 1 percent were children
(under 13 years of age). Of adults/adolescents reported during the 12 months period of
July 1996June 1997, 36 percent were white, 43 percent were black, and 20 percent
were Hispanic. Men who have sex with men accounted for the largest proportion of reported
cases (38 percent). Among 609 children reported in the those12 months, 15 percent were
white, 63 percent were black, and 21 percent were Hispanic (table 6).Over 90 percent of
these children were infected perinatally. In addition, 29 states that conduct HIV case
surveillance of adults, adolescents, and/or children reported 86,972 persons who were
diagnosed with HIV (excluding persons tested anonymously) but not yet diagnosed with AIDS
(table 22).
Sources:
- CDC: Transmission of HIV Possibly Associated
with Exposure of Mucous Membrane to Contaminated Blood. MMWR July 11, 1997 / Vol. 46 / No.
27
- Enger C., et al., Survival from early, intermediate and late stages
of HIV infection . JAMA 1996; 275:1329-34)
-
U.S. HIV and AIDS cases reported through June 1997, Midyear edition
Vol. 9, No. 1 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Centers
for Disease Control and Prevention National Center for HIV, STD, and TB Prevention
Atlanta, Georgia 30333.
NOTE: A complete copy of the
report
(http://www.cdc.gov/nchstp/hiv_aids/stats/hasrlink.htm) referred to in note b may be viewed on the Health and Human Services Pages in
PDF format. As you will be leaving this self-study module, you will have to use your
browser's back key to return to this page.
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